Patent · US Active

Phosphonate ester derivatives and methods of synthesis thereof

US8569321B2 · kind B2 · utility

24Cited by

8References

11Claims

0Family size

Assignee

CHIMERIX, INC. · US

Inventors

Roy W. Ware · Raleigh, US
Merrick R. Almond · Apex, US
Bernhard M. Lampert · Roxboro, US

Key dates

Filing date	Aug 31, 2011
Grant date	Oct 29, 2013
Priority date	—
Expiry date	Aug 31, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.