Methods for treating spinal cord injury with a compound that inhibits a NCCA-ATP channel

US8569377B2 · kind B2 · utility

Assignees

• The United States of America as represented by the Department of Veteran Affairs · US
• UNIVERSITY OF MARYLAND, BALTIMORE · US

Inventor

• J. Marc Simard · Baltimore, US

Key dates

• Filing date: Dec 9, 2010
• Grant date: Oct 29, 2013
• Expiry date: Dec 9, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to therapeutic compositions targeting the NCCa-ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same. More specifically, antagonists of the NCCa-ATP channel are contemplated. The compositions are used to prevent cell death and to treat secondary damage associated with spinal cord injury.