Antibody constant domain regions and uses thereof
US8569460B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 4, 2010 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Feb 26, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/734
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides recombinant protein (e.g., a recombinant antibody or soluble receptor) having (i) a binding domain capable of specific binding to an epitope (for example an antibody variable domains, a receptor, a growth factor, a cytokine, or a fragment of any of the foregoing which is capable of specifically binding the desired epitope) and (ii) an effector domain comprising a constant domain region which is derived from immunoglobulin of a first species which is a companion mammal, e.g. dog, cat, or horse, having engineered substitutions at one or more positions and having an altered interaction with one or more FcRs or other ligands, and optionally enhanced effector function, relative to the parent constant domain region.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.