Patent · US Active

Stem cell beacon

US8569471B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignee

University of South Florida · US

Inventors

M. Phillips · Gainesville, US
Yao Tang · Claremont, US

Key dates

Filing date	Nov 18, 2011
Grant date	Oct 29, 2013
Priority date	—
Expiry date	Nov 18, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/85
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to methods and compositions for selectively directing stem cells to a target tissue within a subject using a system that employs one or more vectors that contain a gene switch/biosensor, a tissue-specific promoter, a gene encoding a stem cell-attracting chemokine, and a gene amplification system. In one embodiment, a stem cell-attracting chemokine is expressed in damaged tissue using a stimulus-responsive vector system. The stimulus can be a physiological stimulus associated with cell injury, such as hypoxia or elevated glucose levels, for example. Expression of the chemokine increases the trafficking of stem cells to the damaged tissue.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.