Method for preparing oligonucleotide
US8569476B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Sep 22, 2009 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Jun 11, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing oligonucleotide comprising reacting the compound of Formula (1) with the compound of Formula (2) in a liquid reaction medium under the condition of condensation reaction to obtain the compound of formula (3) is provided. 1-(2-mesitylenesulfonyl)-3-nitro-1H-1,2,4-triazole (MSNT) is applied as condensing agent. Oligonucleotides synthesized in the liquid reaction medium could be obtained on a large scale.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.