Synthetic method for montelukast sodium intermediate
US8569508B2 · kind B2 · utility
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Key dates
| Filing date | Aug 24, 2010 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Oct 31, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A synthesis method for preparing Montelukast sodium intermediate 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol is provided. In this method, the target compound is prepared by condensing the starting materials 7-chloroquinaldine and 3-cyanobenzaldehyde, and then reacting the resultant product with 2-(2-ortho-(2-haloethyl)-phenylpropyl)tetrahydropyrane ether. The present invention can easily obtain start materials and is applicable for mass production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.