Process for the preparation of dispiro 1,2,4-trioxolane antimalarials (OZ277)

US8569519B2 · kind B2 · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Gyan Chand Yadav · Ghaziabad, IN
• Harish N. Dorwal · Manesar, IN
• Srinivas Valavala · Darsi, IN
• Vinod Kumar Sharma · Faridabad, IN

Key dates

• Filing date: May 24, 2007
• Grant date: Oct 29, 2013
• Expiry date: Jun 3, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D323/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to an improved process for the preparation of a compound of Formula (I), salts of the free base cis-adamantane-2-spiro-3′-8′-[[[(2′-amino-2′-methyl propyl)amino]carbonyl]methyl]-1′,2′,4′-trioxaspiro[4.5]decane wherein X can be an anion.