Substituted benzoylamino-indan-2-carboxylic acids and related compounds

US8569535B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Thomas J. Caulfield · Lawrenceville, US
• Jennifer Clemens · Somerville, US
• Robert S. Francis · Easton, US
• Brian S. Freed · Phillipsburg, US
• Stanly John · Bound Brook, US
• Tieu-Binh Le · Bound Brook, US
• Brian Pedgrift · Morristown, US
• Antonio Daniel Ramos · Flemington, US
• Gerard Rosse · Exton, US
• Martin Smrcina · Tucson, US
• David Squire Thorpe · Tucson, US
• William Wire · Tucson, US
• Jianhong ZHAO · Carteret, US

Key dates

• Filing date: Nov 30, 2009
• Grant date: Oct 29, 2013
• Expiry date: Jul 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds of the formula Ia:in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity, and are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.