Nanoparticle contrast agents for diagnostic imaging

US8574549B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Matthew David Butts · Rexford, US
• Robert Edgar Colborn · Niskayuna, US
• Peter John Bonitatibus, Jr. · Saratoga Springs, US
• Amit Mohan Kulkarni · Clifton Park, US
• Bruce A. Hay · Groton, US
• Andrew Soliz Torres · Niskayuna, US
• Brian Christopher Bales · Niskayuna, US
• Michacl Ernest Marino · Clifton Park, US

Key dates

• Filing date: Dec 29, 2008
• Grant date: Nov 5, 2013
• Expiry date: May 13, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.