Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties

US8574660B2 · kind B2 · utility

Assignee

• Semprus Biosciences Corp. · US

Inventors

• Douglas Weaver · Bedford, US
• Jun Li · Ningbo City, CN
• Zheng Zhang · Cambridge, US
• Abby N. Deleault · Cambridge, US
• Eric W. Marchese · Cambridge, US
• Phu C. Nguyen · Cambridge, US
• Chad C. Huval · Somerville, US
• Michael A. Bouchard · Wyomissing, US
• Arthur J. Coury · Windom, US
• Christopher R. Loose · Cambridge, US

Key dates

• Filing date: Jun 9, 2011
• Grant date: Nov 5, 2013
• Expiry date: Jan 5, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31609
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.