Method for predicting the response to a therapy

US8574834B2 · kind B2 · utility

Assignee

• Index Pharmaceuticals AB · SE

Inventors

• Nikolai Kouznetsov · Järfälla, SE
• Lisa Charlotta Bandholtz · Stockholm, SE
• Alexander Gielen · Stuvsta-Snättringe, SE
• Oliver Von Stein · Upplands Väsby, SE
• Petra Von Stein · Spånga, SE

Key dates

• Filing date: Dec 12, 2008
• Grant date: Nov 5, 2013
• Expiry date: Dec 25, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention concerns an in vitro method for selecting the therapy for a steroid resistant patient, wherein the method comprises isolating cells from a sample taken from said patient; cultivating said isolated cells in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof; determining an expression level of at least one marker gene in said isolated cells; and comparing said expression level of said at least one marker gene to a value obtained from the cultivation of cells from a healthy person in the presence of a steroid, an immunomodulatory oligonucleotide or a mixture thereof, or to a normalized value obtained from a healthy population. Examples of marker genes are CD163, Tsp1, IL1-R2, TLR2, TLR4, MKP-1 and TXK.