Patent · US Active

Methods and assays for identifying compounds that modulate protein-protein interactions

US8574865B2 · kind B2 · utility

1Cited by

6References

26Claims

0Family size

Assignee

Sanofi · FR

Inventors

Paul S. Wright · New Hope, US
Paul Weissensee · Andover, US
Haifeng Eishingdrelo · Montville, US
Jidong Cai · Bedminster, US

Key dates

Filing date	Aug 28, 2008
Grant date	Nov 5, 2013
Priority date	—
Expiry date	Sep 20, 2029

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/10
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Methods and assays for identifying a compound that modulates a protein-protein interaction between a first and a second protein. The methods and assays require a protease that is attached to the second protein and a split and rearranged reporter activating protein that is attached to the first protein, wherein the reporter activating protein comprises a cleavage site for the protease that is interposed between two portions of the reporter activating protein and wherein the two portions of the reporter activating protein are in a rearranged order.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.