Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds

US8574876B2 · kind B2 · utility

Assignee

• Codexis, Inc. · US

Inventors

• Benjamin Mijts · Redwood City, US
• Sheela Muley · Fremont, US
• Jack Liang · San Mateo, US
• Lisa Marie Newman · San Jose, US
• Xiyun Zhang · Fremont, US
• James Lalonde · Palo Alto, US
• Michael D. Clay · Menlo Park, US
• Jun Zhu · Chandler, US
• John M. Gruber · Cameron Park, US
• Jeffrey Colbeck · Davis, US
• John D. Munger, Jr. · Milpitas, US
• Jagadeesh Mavinahalli · Jamkhed, IN
• Roger Sheldon · Rijswijk, NL

Key dates

• Filing date: Mar 30, 2012
• Grant date: Nov 5, 2013
• Expiry date: Mar 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y104/03004
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas,wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.