Methods for sterilizing materials containing biologically active agents

US8574897B2 · kind B2 · utility

Assignee

• DePuy Synthes Products, Inc. · US

Inventors

• Alexander M. Harmon · Clinton, US
• Laura J. Brown · Hamilton Square, US
• Charles J. Buckle · Fryeburg, US
• Frederick Halperin · Fryeburg, US
• Stanko Bodnar · Whitehouse Station, US

Key dates

• Filing date: Jun 8, 2012
• Grant date: Nov 5, 2013
• Expiry date: Jun 8, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L27/38
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.