Patent · US Active

Tc and Re labeled radioactive glycosylated octreotide derivatives

US8575100B2 · kind B2 · utility

2Cited by

2References

8Claims

0Family size

Assignee

MALLINCKRODT LLC · US

Inventors

Hans-Jürgen Wester · Ilmmünster, DE
Margret Schottelius · Munich, DE
Markus Schwaiger · Munich, DE

Key dates

Filing date	Sep 10, 2009
Grant date	Nov 5, 2013
Priority date	—
Expiry date	Jul 22, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Improved sst-receptor binding peptidic ligands for diagnostic and therapeutic applications in nuclear medicine are provided. The improved ligands contain either natural or unnatural amino acids or peptidomimetic structures that are modified at either the N-terminal or the C-terminal end or at both termini, a carbohydrate unit and a chelator or prosthetic group to provide a complexation of a radioisotope binding or holding the radioisotope. The sst- or SSTR-receptor binding peptidic ligands may also contain one or more multifunctional linker units optionally coupling the peptide, and/or the sugar moiety and/or the chelator and/or the prosthetic group. Upon administering the ligand to a mammal through the blood system the ligand provides improved availability, clearance kinetics, sst-receptor targeting and internalization over the non-carbohydrated ligands.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.