Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1

US8575156B2 · kind B2 · utility

Assignee

• Vitae Pharmaceuticals, LLC · US

Inventors

• David A. Claremon · Audubon, US
• Wei He · Audubon, US
• Gerard McGeehan · Chester Springs, US
• Suresh B. Singh · Kendall Park, US
• Colin M. Tice · Ambler, US
• Zhenrong Xu · Forest Park, US
• Yuanjie Ye · Ambler, US
• Wei Zhao · North Potomac, US
• Linghang Zhuang · Doylestown, US
• Salvacion Cacatian · Conshohocken, US
• Katerina Leftheris · Skillman, US

Key dates

• Filing date: Jul 25, 2008
• Grant date: Nov 5, 2013
• Expiry date: May 23, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds represented by Formula (I):or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.