Patent · US Active

Method for early diagnosis of carcinomas of the anogenital tract

US8575326B2 · kind B2 · utility

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0References

20Claims

0Family size

Assignee

Oncgnostics GmbH · DE

Inventors

Matthias Durst · Hanau, DE
Alfred Hansel · Jena, DE
Daniel Steinbach · Lichtentanne, DE

Key dates

Filing date	Sep 17, 2010
Grant date	Nov 5, 2013
Priority date	—
Expiry date	Sep 17, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/16
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for the early diagnosis of carcinomas of the anogenital tract, preferably of the cervical carcinoma, and the preliminary stages thereof is described. The method is based on the determination of the methylation status of segments of the gene regions of ASTN1 (astrotactin 1) and ZNF671 (zinc finger protein 671, transcription factor). A DNA methylation in the promoter region or the 5′-region of these genes is indicative for carcinomas of the anogenital tract or severe preliminary stages thereof. The present invention also relates to kits which permit the conduction of the diagnostic method according to the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.