Patent · US Active

Synthesis and use of 2′-substituted-N6-modified nucleosides

US8575331B2 · kind B2 · utility

0Cited by

1References

14Claims

0Family size

Assignee

Valeant Pharmaceuticals North America · US

Inventors

Haoyun An · Beijing, CN
Kanda Ramasamy · Aliso Viejo, US
Stephanie Shaw · Walnut, US

Key dates

Filing date	Sep 7, 2010
Grant date	Nov 5, 2013
Priority date	—
Expiry date	Sep 7, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.