Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

US8575362B2 · kind B2 · utility

Assignee

• LEXICON PHARMACEUTICALS, INC. · US

Inventors

• Mark S. Bednarz · Yardley, US
• Hugh Alfred Burgoon · Hillsborough Township, US
• Shinya Iimura · Lawrenceville, US
• Ramanaiah C. Kanamarlapudi · Bound Brook, US
• Qiuling Song · Newark, US
• Wenxue Wu · Princeton Junction, US
• Jie Yan · Nanhu, CN
• Haiming Zhang · Pennington, US

Key dates

• Filing date: Jun 15, 2011
• Grant date: Nov 5, 2013
• Expiry date: Jun 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Methods useful for preparing compounds of formula I:and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.