Peptide-coated cell localization to diseased or damaged tissues and methods related thereto
US8580749B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 7, 2010 |
| Grant date | Nov 12, 2013 |
| Priority date | — |
| Expiry date | May 5, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embodiments of the present invention are directed to a coated cell comprising a therapeutic cell and a plurality of targeting complexes coating the therapeutic cell and each of said targeting complexes comprising a homing molecule, a lipid moiety, and a spacer having from about 1 to about 10 amino acids and covalently linking the homing molecule to the lipid moiety and wherein the lipid moiety is non-covalently attached to the therapeutic cell. In some embodiments, the therapeutic cell is a stem cell. Embodiments of the invention are directed to methods of coating a therapeutic cell. Embodiments of the invention are directed to methods of treating diseases of the vasculature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.