Heterocyclic compounds as phosphodiesterase inhibitors

US8580795B2 · kind B2 · utility

Assignee

• ORCHID CHEMICALS & PHARMACEUTICALS LIMITED · IN

Inventors

• Gopalan Balasubramanian · Chennai, IN
• Sukunath Narayanan · Chennai, IN
• Ganapavarapu Veera Raghava Sharma · Visakhapatnam, IN
• Lavanya Andiappan · Chennai, IN
• Shridhar Narayanan · Chennai, IN
• Sanjeev Saxena · Chennai, IN
• Sridharan Rajagopal · Bengaluru, IN
• Santosh Vishwakarma · Darsi, IN
• Saravanan Thirunavukkarasu · Chennai, IN

Key dates

• Filing date: Jan 21, 2010
• Grant date: Nov 12, 2013
• Expiry date: Jun 29, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, N-oxides, metabolites and prodrugs thereof. These compounds are phosphodiesterase type 4 (PDE4) inhibitors. They are useful in the treatment of a variety of allergic or inflammatory diseases including asthma, COPD, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, uveitis, NASH and lupus.