Enzymatic synthesis of carba-NAD

US8580949B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Hartmut Duefel · Schlehdorf, DE
• Dieter Heindl · Munich, DE
• Carina Horn · Biblis, DE
• Thomas Meier · Cherbourg, FR
• Rainer Schmuck · Benediktbeuern, DE

Key dates

• Filing date: Jan 25, 2012
• Grant date: Nov 12, 2013
• Expiry date: Jan 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P19/32
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.