Methods and systems for using actuated surface-attached posts for assessing biofluid rheology

US8586368B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Richard Superfine · Chapel Hill, US
• Richard Chasen Spero · Chapel Hill, US
• Adam Shields · Lafayette, US
• Benjamin Aaron Evans · Chapel Hill, US
• Briana Lee Fiser · High Point, US

Key dates

• Filing date: Jun 25, 2010
• Grant date: Nov 19, 2013
• Expiry date: Jul 15, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2291/02827
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods, systems, and computer readable media for using actuated surface-attached posts for assessing biofluid rheology are disclosed. According to one aspect, a method for testing properties of a biofluid specimen includes placing the specimen onto a micropost array having a plurality of microposts extending outwards from a substrate, wherein each micropost includes a proximal end attached to the substrate and a distal end opposite the proximal end, and generating an actuation force in proximity to the micropost array to actuate the microposts, thereby compelling at least some of the microposts to exhibit motion. The method further includes measuring the motion of at least one of the microposts in response to the actuation force and determining a property of the specimen based on the measured motion of the at least one micropost.