Substituted indole compounds having NOS inhibitory activity
US8586620B2 · kind B2 · utility
2Cited by
34References
25Claims
0Family size
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Key dates
| Filing date | May 6, 2011 |
| Grant date | Nov 19, 2013 |
| Priority date | — |
| Expiry date | May 6, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.