Process for the reductive amination of aldehydes and ketones via the formation of macrocyclic polyimine intermediates
US8586793B2 · kind B2 · utility
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Key dates
| Filing date | Jun 29, 2006 |
| Grant date | Nov 19, 2013 |
| Priority date | — |
| Expiry date | Feb 22, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process produces the desired product in very high yields with low levels of secondary amine impurities.
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