Humanized antibodies that sequester amyloid beta peptide

US8591894B2 · kind B2 · utility

Assignees

• ELI LILLY AND COMPANY · US
• Washington University · US

Inventors

• David Holtzman · Chesterfield, US
• Ronald DeMattos · Noblesville, US
• Kelly R. Bales · Indianapolis, US
• Steven M. Paul · Carmel, US
• Naoya Tsurushita · Palo Alto, US
• Maximiliano Vasquez · Palo Alto, US

Key dates

• Filing date: Dec 22, 2010
• Grant date: Nov 26, 2013
• Expiry date: Jul 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.