Mycobacterial mutants inducing IL-12
US8591918B2 · kind B2 · utility
1Cited by
8References
25Claims
0Family size
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Key dates
| Filing date | Mar 10, 2008 |
| Grant date | Nov 26, 2013 |
| Priority date | — |
| Expiry date | Feb 15, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are mycobacteria deleted in at least a portion of a region 3 ESAT-6-like gene cluster. Also provided are mycobacteria comprising a mutation in an roc-1 gene. Additionally, vaccines comprising these mycobacteria are provided. Further provided are methods of making a recombinant mycobacterium, methods of inducing an immune response in a mammal, methods of inhibiting IL-12 production in a mammal, and methods of stimulating IL-12 production in a mammal. Vaccine adjuvants are also provided, as are methods of inducing immunity to a target antigen in a mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.