Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1

US8592410B2 · kind B2 · utility

Assignees

• Vitae Pharmaceuticals, LLC · US
• Boehringer Ingelheim International GmbH · DE

Inventors

• David A. Claremon · Audubon, US
• Linghang Zhuang · Doylestown, US
• Katerina Leftheris · Skillman, US
• Colin M. Tice · Ambler, US
• Yuanjie Ye · Ambler, US
• Suresh B. Singh · Kendall Park, US
• Frank Himmelsbach · Mittelbiberach, DE

Key dates

• Filing date: Apr 30, 2009
• Grant date: Nov 26, 2013
• Expiry date: Sep 22, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel compounds of the Formula Il Ik, Im3, Im4, Im6-12, In3, In4, In6-12, lo3, lo4, lo6-12, Ip2, Ip4-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.