5-amino-4-hydroxypentoyl amides

US8592429B2 · kind B2 · utility

Assignee

• Janssen R & D Ireland · IE

Inventors

• Genadiy Kalayanov · Huddinge, SE
• Bart Rudolf Romanie Kesteleyn · Berlare, BE
• Kevin Parkes · Letchworth, GB
• Bengt Bertil Samuelsson · Skärholmen, SE
• Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
• Johannes Wilhelmus John F. Thuring · Ekeren, BE
• Hans Wallberg · Stuvsta-Snättringe, SE
• Jörg Kurt Wegner · Mechelen, BE

Key dates

• Filing date: Dec 10, 2010
• Grant date: Nov 26, 2013
• Expiry date: Dec 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

HIV inhibitors of formula (I) wherein R1 is halo, C1-4 alkoxy, trifluoromethoxy; R2 is a group of formula (A); R3 is a group of formula (B); R4 is a group of formula (C); n is 0 or 1; A is CH or N; R5 and R6 are hydrogen, C1-4 allyl, halo; R7 and R8 are C1-4 allyl or C1-4 alkoxy-C1-4 alkyl; R9 is C1-4 allyl, cyclopropyl, trifluoromethyl, C1-4 alkoxy, or dimethylamino; R10 is hydrogen, C1-4 alkyl, cyclopropyl, trifluoromethyl, C1-4 alkoxy, or dimethylamino; pharmaceutically acceptable addition salts and solvates thereof; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds.