Patent · US Active

Context driven image mining to generate image-based biomarkers

US8594410B2 · kind B2 · utility

12Cited by

38References

15Claims

0Family size

Assignee

Definiens GmbH · DE

Inventors

Guenter Schmidt · Leun, DE
Gerd Binnig · Richterswil, CH
Ralf Schoenmeyer · Gilching, DE
Arno Schaepe · Starnberg, DE

Key dates

Filing date	Jan 18, 2011
Grant date	Nov 26, 2013
Priority date	—
Expiry date	Nov 21, 2031

Classification

Technology area (CPC G)Physics
CPC primaryG06T2207/30068
WIPO fieldComputer technology
WIPO sectorElectrical engineering

Abstract

An image-based biomarker is generated using image features obtained through object-oriented image analysis of medical images. The values of a first subset of image features are measured and weighted. The weighted values of the image features are summed to calculate the magnitude of a first image-based biomarker. The magnitude of the biomarker for each patient is correlated with a clinical endpoint, such as a survival time, that was observed for the patient whose medical images were analyzed. The correlation is displayed on a graphical user interface as a scatter plot. A second subset of image features is selected that belong to a second image-based biomarker such that the magnitudes of the second image-based biomarker for the patients better correlate with the clinical endpoints observed for those patients. The second biomarker can then be used to predict the clinical endpoint of other patients whose clinical endpoints have not yet been observed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.