Methods of monitoring a human anti-human antibody response and inhibitors thereof
US8597615B2 · kind B2 · utility
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31References
25Claims
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Key dates
| Filing date | May 8, 2012 |
| Grant date | Dec 3, 2013 |
| Priority date | — |
| Expiry date | May 8, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/56
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present embodiments relate to methods of identifying and creating human or humanized antibodies that possess a reduced risk of inducing a Human Anti-Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included. Methods for determining if various conditions for administering an antibody to a subject enhance or suppress a HAHA response are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.