Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby

US8597666B2 · kind B2 · utility

Assignee

• TEVA PHARMACEUTICAL INDUSTRIES, LTD. · IL

Inventors

• Ilan Zalit · Rosh HaAyin, IL
• Fanny Leska · Herzliya, IL
• Mali Kadosh · Kfar Sava, IL
• Dorit Marco · Rehovot, IL
• Yonit Messer-Triger · Even Yehuda, IL

Key dates

• Filing date: Oct 28, 2011
• Grant date: Dec 3, 2013
• Expiry date: Oct 28, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.