Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8598160B2 · kind B2 · utility
4Cited by
68References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 13, 2009 |
| Grant date | Dec 3, 2013 |
| Priority date | — |
| Expiry date | Jun 4, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D265/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 1a1-3-1j1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.