Pyrazole-carboxamide derivatives as P2Y12 antagonists

US8598179B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Marc Nazare · Idstein, DE
• Gernot ZECH · Frankfurt am Main, DE
• Jochen Goerlitzer · Frankfurt am Main, DE
• Melitta Just · Langen, DE
• Tilo Weiss · Frankfurt am Main, DE
• Gerhard Hessler · Hofheim, DE
• Werngard Czechtizky · Frankfurt, DE
• Sven Ruf · Mainz, DE

Key dates

• Filing date: Jun 17, 2010
• Grant date: Dec 3, 2013
• Expiry date: Jun 17, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the formula I,whereinR1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable, e.g., for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.