Trypsin-like serine protease inhibitors, and their preparation and use

US8598206B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Peter Herold · Allschwil, CH
• Mohammed Daghish · Leipzig, DE
• Stjepan Jelakovic · Allschwil, CH
• Friedrich-Alexander Ludwig · Leipzig, DE
• Claudia Reichelt · Leipzig, DE
• Alexander Schulze · Bad Liebenwerda, DE
• Andrea Schweinitz · Jena, DE

Key dates

• Filing date: Jan 28, 2011
• Grant date: Dec 3, 2013
• Expiry date: Aug 11, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin adhesives. The invention further provides methods of making and using the compounds.