Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US8598316B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 26, 2010 |
| Grant date | Dec 3, 2013 |
| Priority date | — |
| Expiry date | Sep 25, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.