Efficient methods for Z- or cis-selective cross-metathesis

US8598400B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Trustees of Boston College · US

Inventors

• Amir H. Hoveyda · Belmont, US
• Simon J. Meek · Newton, US
• Robert V. O'Brien · Watertown, US
• Josep Llaveria Cros · Tarragona, ES
• Richard R. Schrock · Winchester, US

Key dates

• Filing date: Feb 8, 2011
• Grant date: Dec 3, 2013
• Expiry date: Dec 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.