Methods of treating cancer with human monoclonal antibodies against interleukin 8

US8603469B2 · kind B2 · utility

Assignee

• GENMAB A/S · DK

Inventors

• Jessica Teeling · Krommenie, NL
• Paul Parren · Utrecht, NL
• Ole Baadsgaard · Malmö, SE
• Debra Hudson · Livermore, US
• Jorgen Petersen · Avenue Madeleine, DK

Key dates

• Filing date: Dec 27, 2011
• Grant date: Dec 10, 2013
• Expiry date: Dec 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.