Methods and compositions for enhanced expression and secretion of proteins
US8603780B2 · kind B2 · utility
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Key dates
| Filing date | Jul 16, 2012 |
| Grant date | Dec 10, 2013 |
| Priority date | — |
| Expiry date | Jul 16, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Optimized signal peptide coding sequences for enhanced expression and secretion of protein from a cell and related compositions and methods are described. The optimized signal peptide coding sequence encodes an mRNA that contains at least one hairpin structure immediately downstream of the initiation codon. Methods for obtaining the optimized signal peptide coding sequences and methods for enhanced expression and secretion of proteins using the optimized signal peptide coding sequences are also described.
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