Patent · US Active

Solid phase electrochemical synthesis with controlled product cleavage

US8603803B2 · kind B2 · utility

3Cited by
38References
29Claims
0Family size

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Inventors

Key dates

Filing dateDec 8, 2008
Grant dateDec 10, 2013
Priority date—
Expiry dateNov 24, 2030

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10T436/143333
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Methods for electrochemically synthesizing polymers are provided in which a cleavable linker is coupled to the surface of at least one electrode of an array of electrodes on a substrate and a polymer coupled to the cleavable linker is synthesized through a series of monomer addition cycles. Polymers that are synthesized include nucleic acids and peptides. Cleavable linkers include linkers that can be cleaved under conditions such as reducing, oxidizing, acidic, and or basic conditions. Additionally, provided are devices that comprise an array of individually addressable electrodes having surface-attached cleavable linker molecules.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.