Patent · US Active

Method of inhibiting nonsense-mediated mRNA decay

US8603814B2 · kind B2 · utility

4Cited by

5References

3Claims

0Family size

Assignee

Rutgers, the State University of New Jersey · US

Inventors

Tsafi Pe'ery · Montclair, US
Michael B. Mathews · Montclair, US
Mainul Hogue · North Arlington, US
Hartmut Hanauske-Abel · Edgewater, US

Key dates

Filing date	Jul 20, 2010
Grant date	Dec 10, 2013
Priority date	—
Expiry date	Nov 17, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.