Process for improved protein expression by strain engineering
US8603824B2 · kind B2 · utility
30Cited by
221References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 26, 2005 |
| Grant date | Dec 10, 2013 |
| Priority date | — |
| Expiry date | Nov 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The invention is a process of comparing two genetic profiles of a cell that expresses a recombinant protein and modifying the cell to change the expression of a gene product that is upregulated in response to the recombinant protein expression. The process can improve protein production or can improve protein quality, for example, by increasing solubility of a recombinant protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.