Insulin derivatives having an extremely delayed time-action profile

US8603970B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Paul Habermann · Solms, DE
• Gerhard Seipke · Hofheim, DE
• Roland Kurrle · Frankfurt am Main, DE
• Gunter Muller · Frankfurt am Main, DE
• Mark Sommerfeld · Frankfurt am Main, DE
• Norbert Tennagels · Siegburg, DE
• Georg Tschank · Frankfurt am Main, DE
• Ulrich Werner · Frankfurt am Main, DE

Key dates

• Filing date: Jun 22, 2010
• Grant date: Dec 10, 2013
• Expiry date: Jun 22, 2030

Classification

• Technology area (CPC —): General

Abstract

The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.