Moenomycin analogs, methods of synthesis, and uses thereof

US8604004B2 · kind B2 · utility

Assignee

• President and Fellows of Harvard College · US

Inventors

• Daniel Kahne · Brookline, US
• Suzanne Walker Kahne · Princeton, US
• Masaatsu Adachi · Nagoya, JP
• Emma Doud · Chicago, US
• Shinichiro Fuse · Cambridge, US
• Xiaonan Lin · Mendota Heights, US
• Yi Zhang · Belmont, US
• Hirokazu Tsukamoto · Sendai, JP
• Bohdan Omelyanovich Ostash · Lviv, UA

Key dates

• Filing date: Oct 3, 2008
• Grant date: Dec 10, 2013
• Expiry date: Nov 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H11/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.