Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
US8604052B2 · kind B2 · utility
92Cited by
38References
18Claims
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Key dates
| Filing date | Jul 10, 2013 |
| Grant date | Dec 10, 2013 |
| Priority date | — |
| Expiry date | Jul 10, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases due to mutations in Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.