Process for the preparation of roflumilast

US8604064B2 · kind B2 · utility

Assignee

• TAKEDA GMBH · DE

Inventors

• Bernhard Kohl · Konstanz, DE
• Bernd Mueller · Konstanz, DE
• Walter Palosch · Rielasingen-Worblingen, DE

Key dates

• Filing date: Apr 10, 2013
• Grant date: Dec 10, 2013
• Expiry date: Apr 10, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/75
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.