Chemically programmable immunity
US8604184B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 5, 2010 |
| Grant date | Dec 10, 2013 |
| Priority date | — |
| Expiry date | Dec 24, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.