Osteochondral implants, arthroplasty methods, devices, and systems

US8608801B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• The Curators of the University of Missouri · US

Inventors

• Clark T. Hung · Ardsley, US
• Gerard A. Ateshian · New York, US
• Eric Lima · New York, US
• James L. Cook · Columbia, US
• Li Ming Bian · New York, US

Key dates

• Filing date: Jul 6, 2009
• Grant date: Dec 17, 2013
• Expiry date: Jul 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/76
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.