Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
US8609621B2 · kind B2 · utility
19Cited by
39References
41Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2011 |
| Grant date | Dec 17, 2013 |
| Priority date | — |
| Expiry date | Mar 19, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.