SMAC mimetic compounds as apoptosis inducers
US8609685B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Nov 5, 2008 |
| Grant date | Dec 17, 2013 |
| Priority date | — |
| Expiry date | Mar 4, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0808
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.